 
        
          NOTICE OF ROAD CLOSURE
        
        
          Ali‘i Drive will be closed from
        
        
          Palani Road to Hualalai Road
        
        
          SATURDAY, SEPTEMBER 5
        
        
          at dusk for
        
        
          1
        
        
          /
        
        
          2
        
        
          hour for a torch parade
        
        
          Ka‘ahumanu Place will be
        
        
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          FRIDAY, SEPT. 4  •  SATURDAY, SEPT. 5
        
        
          SUNDAY, SEPT. 6
        
        
          QUEEN
        
        
          LILI‘UOKALANI
        
        
          OUTRIGGER
        
        
          CANOE
        
        
          RACES
        
        
          KAI ‘O– PUA CANOE CLUB
        
        
          will be holding a Craft Fair on Sat. Sept. 5 & Sun. Sept. 6
        
        
          in conjunction with the Queen Lili‘uokalani Canoe Races.
        
        
          
            Mahalo for your understanding.
          
        
        
          
            KAILUA PIER
          
        
        
          Likana Lane
        
        
          
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            d
          
        
        
          
            Ka‘ahumanu Place – closed
          
        
        
          Sarona Rd
        
        
          Kahikina
        
        
          Lane
        
        
          Hualalai Road
        
        
          
            ALI‘I DRIVE
          
        
        
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          K AI LUA BAY
        
        
          Come visit our Logo Shop in the
        
        
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          Thursday Sept. 3 – Sunday, Sept. 6
        
        
          C A L L 9 3 8 - 8 5 7 7 F O R I N F O R M A T I O N
        
        
          
            UP COUNTRY
          
        
        
          
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            Christ Church Episcopal,
          
        
        
          81-1004 KONAWAENA SCHOOL ROAD,
        
        
          KEALAKEKUA, HI 96750
        
        
          Corner of Mamahaloha Hwy (Highway 11)
        
        
          & Konaweana School Road
        
        
          Just Below Konaweana High School
        
        
          Call
        
        
          808-769-4343
        
        
          for info/ directions
        
        
          Water Slide, Ono Grinds, Magic Show, Games and
        
        
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          9A
        
        
          west hawaii today | wednesday, september 2, 2015
        
        
          Obese at 50?
        
        
          WASHINGTON
        
        
          —
        
        
          One more reason to
        
        
          watch the waistline:
        
        
          New research says peo-
        
        
          ple’s weight in middle
        
        
          age may influence not
        
        
          just whether they go on
        
        
          to develop Alzheimer’s
        
        
          disease, but when.
        
        
          Obesity in midlife
        
        
          has long been suspect-
        
        
          ed of increasing the
        
        
          risk of Alzheimer’s.
        
        
          Researchers at the
        
        
          National Institutes of
        
        
          Health took a closer look
        
        
          and reported Tuesday
        
        
          that being overweight
        
        
          or obese at age 50 may
        
        
          affect the age, years
        
        
          later, when Alzheimer’s
        
        
          strikes. Among those
        
        
          who eventually got sick,
        
        
          more midlife pounds
        
        
          meant an earlier onset
        
        
          of disease.
        
        
          It will take larger stud-
        
        
          ies to prove if the flip
        
        
          side is true — that keep-
        
        
          ing trim during middle
        
        
          age might stall later-in-
        
        
          life Alzheimer’s. But it
        
        
          probably won’t hurt.
        
        
          “Maintaining a healthy
        
        
          BMI at midlife is likely
        
        
          to have long-lasting pro-
        
        
          tective effects,” said Dr.
        
        
          Madhav Thambisetty of
        
        
          NIH’s National Institute
        
        
          on Aging, who led the
        
        
          study reported in the jour-
        
        
          nal Molecular Psychiatry.
        
        
          About 5 million peo-
        
        
          ple in the U.S. are liv-
        
        
          ing with Alzheimer’s,
        
        
          a number expected to
        
        
          more than double by
        
        
          2050, barring a medi-
        
        
          cal breakthrough, as the
        
        
          population ages.
        
        
          Alzheimer’s starts qui-
        
        
          etly ravaging the brain
        
        
          more than a decade
        
        
          before symptoms appear.
        
        
          With a cure so far elusive,
        
        
          researchers are hunting
        
        
          ways to at least delay
        
        
          the disease, and lifestyle
        
        
          changes are among the
        
        
          possible options.
        
        
          To explore obesity’s
        
        
          effects, Thambisetty’s
        
        
          team turned to the
        
        
          Baltimore Longitudinal
        
        
          Study of Aging, one of the
        
        
          longest-running projects
        
        
          to track what happens to
        
        
          healthy people as they
        
        
          get older. They checked
        
        
          the records of nearly
        
        
          1,400 participants who
        
        
          had undergone regular
        
        
          cognitive testing every
        
        
          year or two for about 14
        
        
          years; 142 of them devel-
        
        
          oped Alzheimer’s.
        
        
          The
        
        
          researchers
        
        
          checked how much
        
        
          those
        
        
          Alzheimer’s
        
        
          patients weighed when
        
        
          they were 50 and still
        
        
          cognitively healthy. They
        
        
          tracked BMI, or body
        
        
          mass index, a measure of
        
        
          weight to height. Every
        
        
          step up on the BMI
        
        
          chart predicted that
        
        
          when Alzheimer’s even-
        
        
          tually struck, it would be
        
        
          6½ months sooner.
        
        
          In other words, among
        
        
          this group of Alzheimer’s
        
        
          patients, someone who
        
        
          had been obese — a
        
        
          BMI of 30 — during
        
        
          middle age on aver-
        
        
          age had their dementia
        
        
          strike about a year earli-
        
        
          er than someone whose
        
        
          midlife BMI was 28, in
        
        
          the overweight range,
        
        
          Thambisetty explained.
        
        
          The threshold for
        
        
          being overweight is a
        
        
          BMI of 25.
        
        
          The Alzheimer’s study
        
        
          didn’t track whether the
        
        
          patients’ BMI fluctuat-
        
        
          ed before or after age
        
        
          50. There’s no way to
        
        
          know if losing pounds
        
        
          after that age made a
        
        
          difference in dementia
        
        
          risk, although a healthy
        
        
          weight is recommended
        
        
          for many other reasons.
        
        
          Some of the Baltimore
        
        
          Longitudinal study par-
        
        
          ticipants
        
        
          underwent
        
        
          brain scans during life
        
        
          and autopsies at death.
        
        
          Those tests found people
        
        
          with higher midlife
        
        
          BMIs also had more of
        
        
          the brain-clogging hall-
        
        
          marks of Alzheimer’s
        
        
          years later, even if they
        
        
          didn’t develop dementia.
        
        
          Tuesday’s study adds
        
        
          to previous research
        
        
          linking midlife obesity
        
        
          to a risk of Alzheimer’s,
        
        
          but it’s the first to also
        
        
          find those brain chang-
        
        
          es, a clue important to
        
        
          examine further, said
        
        
          Heather Snyder of the
        
        
          Alzheimer’s Association,
        
        
          who wasn’t involved in
        
        
          the work.
        
        
          Meanwhile,
        
        
          the
        
        
          Alzheimer’s group has
        
        
          long recommended a
        
        
          healthy weight: “What’s
        
        
          good for your heart is
        
        
          good for your brain,”
        
        
          Snyder noted.
        
        
          By LAURAN NEERGAARD
        
        
          The Associated Press
        
        
          Midlife weight may affect
        
        
          when Alzheimer’s hits
        
        
        
          
            (808) 329-4044
          
        
        
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